The Global Fund and the U.S. government work together with partner governments to identify and fill in gaps in national tuberculosis programs and strategies across the globe. The U.S. government’s global tuberculosis efforts are led by USAID. USAID is currently working in 23 priority countries to prevent tuberculosis transmission, renew efforts to find unidentified cases, strengthen the capacity of national tuberculosis programs, build country capacity to use existing resources, and expand the development of new tuberculosis diagnostics, drugs and vaccines. USAID is also one of the main implementers of PEPFAR’s HIV/tuberculosis coinfection programs.

The relationship between the Global Fund and USAID involves close coordination of resources to ensure funding and programs are not duplicative. The organizations work together to ensure programs are reflective of each country’s national strategic plans. As a global health financer, the Global Fund’s role primarily involves providing funds for tuberculosis programs in-country through Principal Recipients (PRs), organizations that lead grant management on the ground. USAID’s in-country staff then partner with the Global Fund as a grant implementer by providing technical assistance to PRs.

Additionally, USAID mobilizes resources for the development of Global Fund concept notes and provides technical assistance to support countries with a high burden of HIV/ tuberculosis co-infection through the development of a single, integrated funding request. The United States plays a key role in many aspects of the Global Fund decision-making process, leveraging its technical expertise and on-the-ground knowledge to help improve program design and grant performance.