PEPFAR, established in 2003, is the U.S. government initiative working to end the global HIV/AIDS epidemic. This initiative, the largest commitment by any nation to combat a single disease internationally, also helps to build health systems and alleviate suffering from other related diseases. As of Sept. 30, 2015, PEPFAR is supporting lifesaving antiretroviral treatment for 9.5 million people. Of these individuals, 5.7 million are receiving direct PEPFAR support. An additional 3.8 million are benefiting from essential technical support to partner countries. The Global Fund and PEPFAR are the two leading global financiers of the HIV/AIDS response, accounting for approximately 80 percent of international assistance and together providing antiretroviral treatment for nearly 17 million people.

The Global Fund and PEPFAR work closely together to build capacity, leverage investments, mobilize resources and provide stable external financing. They collaborate to focus especially on key and vulnerable populations, including adolescent girls and young women. The Global Fund’s primary role is to ensure that there is an integrated, efficient and effective HIV/AIDS response on the country level while PEPFAR utilizes Global Fund resources and works on the ground to provide direct technical support. Additionally, each leverages the comparative advantages of the other — the Global Fund ensures an integrated HIV/AIDS response through PEPFAR’s direct support for the provision of technical care and treatment services, and PEPFAR uses the Global Fund’s bulk pricing and purchasing power to procure commodities for less.

Notably, the U.S. government, through PEPFAR, holds a permanent seat as a member of the Board of the Global Fund and has been actively involved in the Fund’s grant development process. Conversely, PEPFAR has invited the Global Fund to attend and provide input at in-person PEPFAR Country Operational Plan (COP) reviews. PEPFAR has assigned personnel to work from the Global Fund’s headquarters to further enhance communication and collaboration. Since 2005, PEPFAR has provided the Global Fund with technical assistance in such areas as concept note development, grant management and quality improvement. On a country level, the Global Fund’s Geneva-based Fund Portfolio Managers meet with PEPFAR in-country teams on a monthly basis. Finally, PEPFAR and the Global Fund have been working since early 2012 to harmonize financial monitoring and construct a framework to compare expenditure data.